Gene 62 of oka vaccine virus and method for identifying...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/38 (2006.01) A61K 39/25 (2006.01) C07K 14/04 (2006.01) C07K 16/08 (2006.01) C12N 7/04 (2006.01) C12N 7/08 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) C12Q 1/70 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2326699

The present application provides the gene 62 of Oka vaccine virus, which comprises at least with the following base substitutions (a) to (d) in the nucleotide sequence of SEQ ID No. 1: (a) the base A at position 2110 is G; (b) the base A at position 3100 is G; (c) the base T at position 3818 is C; and (d) the base A at position 4006 is G, and a method for identifying the Oka vaccine virus and an attenuated varicella-zoster virus strain acceptable as virus strain for live attenuated varicella vaccine, by using the gene 62.

L'invention concerne un gène 62 de la souche oka du virus de la varicelle présentant la séquence de base représentée par la SEQ ID N0: 1 avec au moins les substitutions de base (a) à (d) comme spécifié ci-après: (a) substitution de A à la position 2110 par G, (b) substitution de A à la position 3100 par G, (c) substitution de T à la position 3818 par G, et (d) substitution de A à la position 4006 par G. L'invention concerne aussi un procédé pour identifier la souche oka du virus de la varicelle atténué et une souche de virus de la varicelle atténué pouvant être utilisée comme souche de virus pour le vaccin de la varicelle vivant et atténué.

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