Vanadate resistance glycosylation 4 gene

Details Vanadate resistance glycosylation 4 gene Vanadate resistance glycosylation 4 gene

C - Chemistry, Metallurgy

12

N

C12N 15/31 (2006.01) C07K 14/39 (2006.01) C07K 16/14 (2006.01) C07K 16/26 (2006.01) C12N 1/00 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2339338

The invention is a Vanadate-Resistant Glycosylation (VRG4) gene and gene product from pathogenic yeast and fungi that encodes a Golgi-nucleotide-sugar transporter. Methods of detecting transporter activity and methods of screening for candidate anti-fungal compounds are disclosed.

L'invention concerne un gène 4 de glycosylation résistant au vanadium (VRG4) et un produit génique issu d'une levure pathogène et de champignons codant un transporteur de sucres nucléotidiques dans le complexe de Golgi. On décrit des procédés pour détecter l'activité du transporteur et des procédés de criblage de composés antifongiques candidats.

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