Use of interleukin-19 to treat ovarian cancer

Details Use of interleukin-19 to treat ovarian cancer Use of interleukin-19 to treat ovarian cancer

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61K 31/337 (2006.01) A61K 31/4745 (2006.01) A61K 31/53 (2006.01) A61K 31/555 (2006.01) A61K 31/704 (2006.01) A61K 31/7048 (2006.01) A61K 33/24 (2006.01) A61K 41/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2480213

The present invention relates to the anti-cancer activity of IL-19 polypeptide molecules. IL-19 is a cytokine involved in inflammatory processes and human disease. The present invention includes use of IL-19 for decreasing proliferation of ovarian cancer cells, treating ovarian cancer, amongst other uses disclosed. IL-19 polypeptides can be administered alone, or can be fused to cytotoxic moieties, and can be administered in conjunction with radiation or chemotherapeutic agents.

L'invention concerne l'activité anticancéreuse de molécules polypeptidiques d'IL-19. IL-19 est une cytokine intervenant dans des processus inflammatoires et des pathologies humaines. L'invention comprend l'utilisation d'IL-19 pour, entre autres, réduire la prolifération de cellules ovariennes cancéreuses et traiter le cancer de l'ovaire. Les polypeptides d'IL-19 peuvent être administrés seuls ou être fusionnés à des fractions cytotoxiques, et peuvent être administrés conjointement avec une radiothérapie ou des agents chimiothérapeutiques.

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