Manufacturing method of combined vaccine

A - Human Necessities – 61 – K

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A61K 39/29 (2006.01) A61K 39/295 (2006.01)

Patent

CA 2434421

The present invention relates to a method for manufacturing a combined vaccine capable of concurrently preventing multiple diseases such as diphtheria, tetanus, pertussis, and hepatitis B which should be prevented in an infant. The method for manufacturing a combined vaccine according to the present invention includes the steps of independently adsorbing each protective antigen to an adsorbent of a aluminum hydroxide gel with respect to various diseases such as diphtheria, tetanus, pertussis, and hepatitis B which should be prevented in the infants, and combining each protective antigen adsorbed to the adsorbent after the adsorption. In the present invention, it is possible to concurrently prevent multiple diseases such as diphtheria, tetanus, pertussis, and hepatitis B which should be prevented in the infant using a combined vaccine manufactured according to the present invention.

La présente invention concerne une méthode de fabrication d'un vaccin combiné permettant de prévenir simultanément plusieurs maladies, telles que la diphtérie, le tétanos, la coqueluche et l'hépatite B, qui devraient être prévenues chez le nourrisson. Cette méthode de fabrication d'un vaccin combiné consiste à adsorber indépendamment chacun des antigènes protecteurs associés à plusieurs maladies, telles que la diphtérie, le tétanos, la coqueluche et l'hépatite B, qui devraient être prévenues chez le nourrisson, sur un adsorbant formé à partir d'un gel d'hydroxyde d'aluminium, puis à combiner chacun des antigènes protecteurs adsorbé. Dans la présente invention, il est possible de prévenir simultanément plusieurs maladies, telles que la diphtérie, le tétanos, la coqueluche et l'hépatite B, qui devraient être prévenues chez le nourrisson, à l'aide d'un vaccin fabriqué selon la méthode de la présente invention.

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