Positron emission tomography imaging method

Details Positron emission tomography imaging method Positron emission tomography imaging method

C - Chemistry, Metallurgy

07

D

C07D 475/04 (2006.01) A61K 51/04 (2006.01) C07B 59/00 (2006.01)

Patent

CA 2677792

Described herein are compositions and methods for diagnosing and/or monitoring pathogenic disease states using positron emission tomography, wherein the pathogenic cells uniquely express, preferentially express, or overexpress vitamin receptors. Also described herein are 18F conjugates of vitamins and vitamin receptor- binding analogs and derivatives.

L'invention concerne des compositions et des procédés pour le diagnostic et/ou la surveillance d'états maladifs pathogènes utilisant une tomographie par émission de positrons, où les cellules pathogènes expriment uniquement, expriment de manière préférentielle, ou surexpriment des récepteurs de vitamine. Des conjugués 18F de vitamines et d'analogues de liant de récepteur de vitamine et des dérivés sont également décrits ici.

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