C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/52 (2006.01) A61K 31/4168 (2006.01) A61K 31/4178 (2006.01) A61K 31/427 (2006.01) A61K 31/4427 (2006.01) A61K 31/4439 (2006.01) A61P 15/10 (2006.01) C07D 233/44 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 417/12 (2006.01)
Patent
CA 2457433
Aspects of the present invention are directed towards compounds of Formula I for the treatment of human erectile disorders including erectile dysfunction in men (I), wherein: R1 is hydrogen, halo, hydroxy, nitro, cyano, phenyl, trifluoromethyl, C1-C6 alkyl, C1- C6 alkoxy, carboxy, amino, cyclohexyl, C1-C6 alkyl amino, or (C1-C6 alkyl)2amino; R2 is hydrogen, halo, hydroxy, nitro, cyano, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, carboxy, amino, C1-.sim.6 alkyl amino, or (C1-C6 alkyl)2amino; R3 is a group of the formula R4 is hydrogen or C1-C6 alkyl; R5 is hydrogen, halo, hydroxy, nitro, cyano, phenyl, trifluoromethyl, C1-C6 alkyl, C1- C6 alkoxy, carboxy, amino, C1-C6 alkylamino, or (C1-C6 alkyl)2amino; and is hydrogen, halo, hydroxy, nitro, cyano, trifluoromethyl, C1-C6 alkyl, C1-C6 alkoxy, carboxy, amino, C1-C6 alkyl amino, or (C1-C6 alkyl)2amino; or pharmaceutically acceptable salts thereof.
dans certains de ces aspects, la présente invention concerne des composés représentés par la formule I destinés au traitement des troubles érectiles humains, dont un dysfonctionnement de l'érection chez l'homme. Dans la formule I: R1 est hydrogène, halo, hydroxy, nitro, cyano, phényle, trifluorométhyle, C¿1?-C¿6? alkyle, C¿1?- C¿6? alkoxy, carboxy, amino, cyclohexyle, C1-C¿6? alkyl amino, ou (C¿1?-C¿6? alkyl)¿2?amino; R¿2? est hydrogène, halo, hydroxy, nitro, cyano, trifluorométhyle, C¿1?-C¿6? alkyle, C¿1?-C¿6? alkoxy, carboxy, amino, C¿1?-.sim.¿6? alkyl amino, ou (C¿1?-C¿6? alkyl)¿2?amino; R¿3? est un groupe de la formule. R¿4? est hydrogène ou C¿1?-C¿6 alkyle; R¿5? est hydrogène, halo, hydroxy, nitro, cyano, phényle, trifluorométhyle, C¿1?-C¿6? alkyle, C¿1?- C¿6? alkoxy, carboxy, amino, C¿1?-C¿6? alkylamino, ou (C¿1?-C¿6? alkyl)¿2?amino; et R?6¿ est hydrogène, halo, hydroxy, nitro, cyano, trifluorométhyle, C¿1?-C¿6? alkyle, C¿1?-C¿6? alkoxy, carboxy, amino, C¿1?-C¿6? alkyl amino, ou (C¿1?-C¿6? alkyl)¿2?amino; ou bien des sels de ces composés acceptables au plan pharmaceutique.
Miller Duane D.
Seoung-Soo Hong
Gowling Lafleur Henderson Llp
Molecular Design International Inc.
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