Small particle liposome aerosols for delivery of anti-cancer...

Details Small particle liposome aerosols for delivery of anti-cancer... Small particle liposome aerosols for delivery of anti-cancer...

A - Human Necessities

61

K

A61K 9/127 (2006.01) A61K 31/03 (2006.01) A61K 31/175 (2006.01) A61K 31/337 (2006.01) A61K 31/4745 (2006.01) A61K 31/505 (2006.01) A61K 31/513 (2006.01) A61K 31/519 (2006.01) A61K 31/52 (2006.01) A61K 38/21 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2303147

The small particle liposome aerosol compounds and methods of treatment of the present invention involve lipid- or water soluble anti-cancer drugs incorporated into liposomes. The liposomes are administered in aqueous dispersions from a jet nebulizer to the respiratory tract of an individual. Various anti-cancer drugs may be used, including 20-S-Camptothecin, 9-Nitro- camptothecin, 9-Amino-camptothecin, 10, 11-methylenedioxy-camptothecin and taxol or its derivatives. Administration of these drugs by inhalation provides faster and more efficient absorption of the anti-cancer drug than does intramuscular administration or oral administration.

Les composés d'aérosols pour liposomes à petites particules et les procédés de traitement de cette invention comprennent des médicaments anticancéreux solubles dans des lipides ou dans de l'eau qui sont intégrés dans des liposomes. Les liposomes sont administrés sous forme de dispersions aqueuses envoyées par un nébuliseur dans le tractus respiratoire d'un individu. Plusieurs médicaments anticancéreux peuvent être utilisés tels que la 20-S-camptothécine, la 9-nitro-camptothécine, la 9-amino-camptothécine, la 10,11-méthylène dioxy-camptothécine, le taxol ou ses dérivés. L'administration de ces médicaments par inhalation assure l'absorption plus rapide et plus efficace du médicament anticancéreux que lorsqu'on l'administre par voie intramusculaire ou par voie orale.

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