Biphenyl carboxylic acids and derivatives thereof

Details Biphenyl carboxylic acids and derivatives thereof Biphenyl carboxylic acids and derivatives thereof

C - Chemistry, Metallurgy

07

C

C07C 59/68 (2006.01) A61K 31/192 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2702832

The present invention relates to compounds having the general Formula (I) with the definitions of R1, R2, R3, and R4 given below, and/or a salt or ester thereof. Furthermore the invention relates to the use of said compounds for the treatment of Alzheimer's disease and their use for the modulation of g-secretase activity.

La présente invention concerne des composés ayant la formule générale (I) avec les définitions de R1, R2, R3, et R4 données ci-dessous, et/ou un sel ou un ester de ceux-ci. En outre, l'invention concerne l'utilisation desdits composés pour le traitement de la maladie d'Alzheimer et leur utilisation pour la modulation de l'activité de la g-secrétase.

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