Pyrrolidine derivatives as metalloprotease inhibitors

Details Pyrrolidine derivatives as metalloprotease inhibitors Pyrrolidine derivatives as metalloprotease inhibitors

C - Chemistry, Metallurgy

07

D

C07D 207/48 (2006.01) A61K 31/40 (2006.01) A61K 31/4192 (2006.01) A61P 9/00 (2006.01) C07D 207/10 (2006.01) C07D 403/06 (2006.01) C07D 405/12 (2006.01)

Patent

CA 2415740

The present invention relates to compounds of formula (I) wherein R1, R2, R3, R4, R5, R6, Y, n, m, o. p and q are as defined in the description and the claims and dimeric forms and/or pharmaceutically acceptable esters, and/or salts thereof. The compounds are useful as inhibitors of metalloproteases, e.g. zinc proteases, particularly zinc hydrolases, and which are effective in treating disease states are associated with vasoconstriction of increasing occurrences.

L'invention concerne des composés de formule (I) dans laquelle R?1¿, R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, Y, n, m, o, p et q sont définis tel que dans la description et dans les revendications, ainsi que des formes dimère, et/ou des esters pharmaceutiquement acceptables et/ou des sels dérivés de ceux-ci. Ces composés sont utiles en tant qu'inhibiteurs de métalloprotéases, par exemple de protéases de zinc, en particulier d'hydrolases de zinc, et sont efficaces dans le traitement d'états pathologiques associés à la vasoconstriction de plus en plus fréquents.

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