Recovering unreacted intermediate from desalinated and...

Details Recovering unreacted intermediate from desalinated and... Recovering unreacted intermediate from desalinated and...

C - Chemistry, Metallurgy

07

C

C07C 231/24 (2006.01) C07C 237/46 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2710107

This invention relates generally to industrial preparation of iodixanol (1,3- bis(acetamido)-N,N'-bis[3,5-bis(2,3-dihydroxypropylaminocarbonyl)-2,4,6- triiodophenyl]-2- hydroxypropane), a non-ionic X-ray contrasting agent. It further relates to a method of recovering intermediate 5-acetamido-N,N'-bis(2,3-dihydroxypropyl)-2,4,6- triiodoisophthalamide ("Compound A") from the desalinated and desolventized dimerisation reaction mixture. In particular, the present invention employs ultrafiltration to recover non-crystalline Compound A to reduce the overall cost of iodixanol manufacture, increase the yield of iodixanol, and facilitate the subsequent purification procedures to meet the regulatory purity requirement of iodixanol.

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