Substituted n-biphenylyl lactams

Details Substituted n-biphenylyl lactams Substituted n-biphenylyl lactams

C - Chemistry, Metallurgy

07

D

C07D 403/10 (2006.01) A61K 31/40 (2006.01) A61K 31/435 (2006.01) A61K 31/675 (2006.01) C07D 209/46 (2006.01) C07D 209/74 (2006.01) C07D 211/86 (2006.01) C07D 401/10 (2006.01) C07F 9/553 (2006.01)

Patent

CA 2082787

ABSTRACT This invention relates to novel N-biphenylyl lactam compounds having a substituted methylidene or methyl moiety adjacent to the lactam nitrogen, and pharmaceutically acceptable salts thereof. The compounds are angiotensin II receptor antagonists, and are useful in treating hypertension (lowering high blood pressure), congestive heart failure, elevated ocular pressure, cerebral stroke, angina, cardiac insufficiency, myocardial infarction or diabetic nephropathy. The invention also relates to a pharmaceutical composition comprising a compound of the invention, a method of treating a physiological condition in a mammal that is mediated by angiotensin II which comprises administering to the mammal an effective amount of a compound of the invention, and novel processes for preparing the compounds of the invention.

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