C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/10 (2006.01) A61K 39/145 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01)
Patent
CA 2663388
The present invention relates to binding molecules such as human monoclonal antibodies that bind to influenza virus H5N1 and have neutralizing activity against influenza virus H5N1. The disclosure provides nucleic acid molecules encoding the antibodies, their sequences and compositions comprising the antibodies and methods of identifying or producing the ant ibodies. The antibodies can be used in the diagnosis, prophylaxis and/or treatment of an influenza virus H5N1 infection. In a preferred embodiment, the antibodies provide cross- subt ype protection in vivo, such that infections with H5, H2, H6, H9 and H1-based influenza subtypes can be prevented and/or treated.
La présente invention concerne des molécules de liaison telles que des anticorps monoclonaux humains qui se lient au virus de la grippe H5N1 et ont une activité neutralisante à l'encontre du virus de la grippe H5N1. La description fournit des molécules d'acide nucléique codant pour les anticorps, leurs séquences et des compositions comprenant les anticorps et des procédés d'identification ou de production des anticorps. Les anticorps peuvent être utilisés dans le diagnostic, la prophylaxie et/ou le traitement d'une infection par le virus de la grippe H5N1. Dans un mode de réalisation préféré, les anticorps fournissent une protection croisée contre des sous-types in vivo, de telle sorte que des infections par des sous-types de la grippe à base de H5, H2, H6, H9 et H1 peuvent être empêchées et/ou traitées.
de Kruif Cornelis Adriaan
Throsby Mark
Van Den Brink Edward Norbert
Borden Ladner Gervais Llp
Crucell Holland B.v.
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