4-aminoquinazoline derivatives

Details 4-aminoquinazoline derivatives 4-aminoquinazoline derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/505 (2006.01) A61K 31/535 (2006.01) C07D 239/74 (2006.01) C07D 239/88 (2006.01) C07D 239/94 (2006.01) C07D 403/04 (2006.01) C07D 403/12 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2218945

Disclosed are novel 4-aminoquinazoline derivatives of the formula (See formula I) (wherein Z is NR3R4 in which R3 is H and R4 is Q2 or phenyl substituted with (R5)q or Z is (See formula II) the dotted line represents an optional double bond; R5 is a substituent such as halo, amino, alkyl, alkoxy, etc.; R6 is a substituent such as hydroxyl, amino, sulfo, alkoxy, carboxyl, etc.; q is 0-3; o is 0-2; Q2 is a 9- or 10-membered bicyclic heterocyclic moiety; Q1 is Ar-Y-X in which Ar is mono- or bicyclic (hetero)aryl, X is alkenylene, alkynylene or bond and Y is (CH2)p where p is 0-5; R1 is a substituent such as trifluoromethyl; n is 0-3; m is 1-2) and their pharmaceutically acceptable salts. Those compounds and the salts are useful for the treatment of hyperproliferative disorders and conditions in mammals.

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