Antibody alpha4beta7 integrin and its use to treat...

A - Human Necessities – 61 – K

Patent

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Details

A61K 39/395 (2006.01) A61K 31/52 (2006.01) A61K 31/57 (2006.01) A61K 31/60 (2006.01) A61K 31/635 (2006.01) A61P 37/06 (2006.01) C07K 16/28 (2006.01)

Patent

CA 2406220

Disclosed is a method for treating a human having a disease associated with leukocyte infiltration of mucosal tissues, comprising administering to said human an effective amount of a human or humanized immunoglobulin or antigen- binding fragment thereof having binding specificity for .alpha.4.beta.7 integrin. Preferably, no more than about 8 mg immunoglobulin or fragment per kg body weight are administered during a period of about one month.

L'invention concerne une méthode permettant de traiter un patient souffrant d'une maladie associée à l'infiltration de leucocytes dans les tissus des muqueuses, consistant à administrer au patient une quantité efficace d'une immunoglobuline humaine ou humanisée ou d'un fragment de liaison à l'antigène de celle-ci présentant une spécificité de liaison à l'intégrine alpha 4ss7. De préférence, on n'administre pas plus d'environ 8 mg d'immunoglobuline ou de fragment par kg pendant une période d'environ un mois.

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