C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 475/04 (2006.01) A61K 31/505 (2006.01) C07D 235/00 (2006.01) C07D 239/00 (2006.01) C07D 241/00 (2006.01) C07D 487/14 (2006.01)
Patent
CA 2545484
Process for the preparation of tetrahydrobiopterin from neopterin and/or 6- substituted pterins with an improved yield and a high stereoselectivity. Also disclosed herein are novel individual intermediates prepared in the preparation of tetrahydrobiopterin, such as selectively protected neopterin useful for the preparation of tetrahydrobiopterin.
La présente invention se rapporte à un procédé de préparation de tétrahydrobioptérine à partir de néoptérine et/ou de ptérines substituées en position 6, ledit procédé présentant un meilleur rendement et une stéréosélectivité élevée. L'invention concerne également de nouveaux intermédiaires formés lors de la préparation de la tétrahydrobioptérine, tels que la néoptérine sélectivement protégée, utile pour préparer la tétrahydrobioptérine.
Groehn Viola
Martin Pierre
Moser Rudolf
Schumacher Andreas
Spielvogel Dirk
Biomarin Pharmaceutical Inc.
Kirby Eades Gale Baker
Merck Eprova Ag
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