C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0789 (2010.01) C12N 5/071 (2010.01) A61K 35/12 (2006.01) A61K 35/28 (2006.01) A61P 7/06 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 37/00 (2006.01) C07D 473/34 (2006.01) C07D 519/00 (2006.01)
Patent
CA 2740589
The present invention relates to compounds and compositions for expanding the number of CD34+ cells for trans-plantation. The invention further relates to a cell population comprising expanded hematopoietic stem cells (HSCs) and its use in autologous or allogeneic transplantation for the treatment of patients with inherited immunodeficient and autoimmune diseases and diverse hematopoietic disorders to reconstitute the hematopoietic cell lineages and immune system defense.
La présente invention porte sur des composés et des compositions pour développer le nombre de lymphocytes CD34+ pour une transplantation. L'invention porte en outre sur une population cellulaire comprenant des cellules souches hématopoïétiques développées (HSC) et sur son utilisation dans une transplantation autologue ou allogène pour le traitement de patients avec des maladies d'immunodéficience et des maladies auto-immunes héréditaires et divers troubles hématopoïétiques pour reconstituer les lignées de cellules hématopoïétiques et la défense du système immunitaire.
Boitano Anthony
Cooke Michael
Pan Shifeng
Schultz Peter G.
Tellew John
Fetherstonhaugh & Co.
Irm Llc
The Scripps Research Institute
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