Process for the preparation of a1 adenosine receptor agonists

Details Process for the preparation of a1 adenosine receptor agonists Process for the preparation of a1 adenosine receptor agonists

C - Chemistry, Metallurgy

07

H

C07H 19/16 (2006.01) A61K 31/7008 (2006.01)

Patent

CA 2573682

Disclosed is a synthesis suitable for large scale manufacture of novel compounds that are partial and full A1 adenosine receptor agonists having the structure of formula (I), wherein R is optionally substituted phenyl, that are useful for treating various disease states, in particular tachycardia and atrial flutter, angina, and myocardial infraction.

Il est exposé une synthèse convenant pour la fabrication à grande échelle de nouveaux composés qui sont des agonistes partiels ou complets du récepteur A1 de l'adénosine, qui ont la structure de formule (I), dans laquelle R est un phényle facultativement substitué, et qui sont utiles pour traiter différentes maladies, en particulier la tachycardie et le flutter auriculaire, l'angine de poitrine et l'infarctus du myocarde.

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