Method of identifying individuals at risk of thiopurine drug...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C12N 15/11 (2006.01) C12N 15/52 (2006.01)

Patent

CA 2703810

The present invention is directed to a method of screening individuals for the presence or absence of one or more polymorphisms within the Guanosine 5' monophosphate synthetase (GMPS) gene that are associated with the risk of thiopurine resistance or intolerance.

La présente invention concerne un procédé de dépistage d'individus, permettant de détecter la présence ou l'absence d'un ou de plusieurs polymorphismes à l'intérieur du gène de la Guanosine 5' monophosphate synthétase (GMPS) associés au risque de résistance ou d'intolérance à la thiopurine.

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