C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/85 (2006.01) A61K 35/74 (2006.01) A61K 38/00 (2006.01) A61K 38/16 (2006.01) A61P 1/00 (2006.01) A61P 29/00 (2006.01) C07K 14/255 (2006.01) C12N 15/31 (2006.01)
Patent
CA 2726193
Methods and products are disclosed for treating an inflammatory intestinal disease in a mammalian subject in need thereof, or preventing or reducing a symptom of inflammatory intestinal disease. These method include administering to the subject a therapeutically effective dose of (i) an isolated AvrA protein or polypeptide fragment thereof or (ii) a nucleic acid molecule encoding the isolated AvrA protein or polypeptide fragment. Preferred inflammatory intestinal diseases include Inflammatory Bowel Disease, Celiac Disease, and gastroenteritis.
L'invention porte sur des procédés et des produits de traitement de maladie intestinale inflammatoire chez un sujet mammifère en ayant besoin, ou pour prévenir ou réduire un symptôme de maladie intestinale inflammatoire. Ces procédés comprennent l'administration au sujet d'une dose thérapeutique efficace (i) d'une protéine AvrA isolée ou d'un fragment peptidique de celle-ci ou (ii) d'une molécule d'acide nucléique codant pour la protéine AvrA isolée ou le fragment peptidique. Les maladies intestinales inflammatoires préférées comprennent l'affection intestinale inflammatoire, la maladie cliaque et la gastroentérite.
Gowling Lafleur Henderson Llp
University Of Rochester
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