Piperazinyl derivatives

Details Piperazinyl derivatives Piperazinyl derivatives

C - Chemistry, Metallurgy

07

D

C07D 295/15 (2006.01) A61K 31/495 (2006.01) C07D 277/62 (2006.01) C07D 295/088 (2006.01) C07D 295/13 (2006.01) C07D 317/66 (2006.01) C07D 319/18 (2006.01) C07D 401/04 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 417/12 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2089768

2089768 9203426 PCTABS00010 Piperazinyl derivatives of general formula (I) wherein R1 represents substituted phenyl, 1- or 2-naphthyl, azanaphtyl or diazanaphtyl groups; n is 1, 2, 3 or 4; X is -O- or (1) wherein R2 is hydrogen, C1-6-alkyl or C3-8-cycloalkyl; Y is =O or =S or =NZ wherein Z is hydrogen, C1-6-alkyl or -CN and R3 is selected from a group consisting of various structures have been found to exhibit high affinity for various receptor subtypes including the 5-HT2 receptor, the 5-HT1A receptor, the alpha1 receptor, the dopamine receptor or a combination of these and may therefore be useful for treating CNS system, cardiovascular system and gastrointestinal disorders.

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