Hybrid picornaviruses expressing chlamydial epitopes

Details Hybrid picornaviruses expressing chlamydial epitopes Hybrid picornaviruses expressing chlamydial epitopes

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 39/118 (2006.01) A61K 39/39 (2006.01) C07K 14/295 (2006.01) C07K 16/12 (2006.01) C12N 7/01 (2006.01) C12N 15/31 (2006.01) C12N 15/41 (2006.01) C12N 15/62 (2006.01) G01N 33/569 (2006.01) A61K 39/00 (2006.01)

Patent

CA 2162664

Hybridpicornaviruses expressing chlamydial epitopes from the major outer membrane protein of Chlamydia trachomatis in a functional form are described. The hybrid viruses grow to high titre in cell culture and when administered to mammals induce an immune response against both the picornavirus and C. trachomatis. The antisera from immunised mammals neutralised both homotypic and heterotypic serovars of C. trachomatis. The hybrid picornaviruses have utility as vaccines and as tools for the generation of immunological reagents. Methods for modifying surface exposed loops of known sequences to produce hybrid proteins are described.

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