Inhibitors of the interaction between p53 and mdm2

Details Inhibitors of the interaction between p53 and mdm2 Inhibitors of the interaction between p53 and mdm2

C - Chemistry, Metallurgy

07

K

C07K 7/08 (2006.01) A61K 31/70 (2006.01) A61K 38/08 (2006.01) A61K 38/10 (2006.01) A61K 48/00 (2006.01) C07K 7/04 (2006.01) C07K 7/06 (2006.01) C07K 14/82 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2259149

The present invention relates to compounds capable of binding to the oncogene protein MDM2, processes for the preparation of such compounds, pharmaceutical preparations comprising such compounds, and uses of said compounds, e.g. in the therapeutic (including prophylactic) treatment of an animal or especially of the human body. The present further relates to methods of and compounds for inhibiting the growth of tumor cells which comprise the wild type p53 suppressor by interfering with the interaction between human p53 and human MDM2.

Composés capables de se lier à la protéine oncogène MDM2, procédés pour préparer ces composants, préparations pharmaceutiques contenant de tels composants et utilisations de ces composants, par exemple dans le traitement thérapeutique (y compris préventif) d'un animal ou plus particulièrement de l'organisme humain. L'invention porte également sur des méthodes et des composants pour inhiber la croissance des cellules tumorales contenant le gène suppresseur p53 de type sauvage, en inhibant l'interaction entre le gène p53 humain et la protéine MDM2 humaine.

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