Process for nitrating aniline derivatives

Details Process for nitrating aniline derivatives Process for nitrating aniline derivatives

C - Chemistry, Metallurgy

07

C

C07C 227/16 (2006.01) C07C 213/08 (2006.01) C07C 219/32 (2006.01) C07C 229/60 (2006.01)

Patent

CA 2367364

The present invention relates to a process for the highly regioselective aromatic nitration of alkyl 4-alkanoylamino-3-alkyl-benzoates in the 5-position in a mixture containing nitric acid and the use of the resulting products for preparing, in particular, pharmaceutically active benzimidazole derivatives.

L'invention concerne un procédé de nitration aromatique hautement régiosélective d'esters d'alkyle d'acide benzoïque de 4-alcanoylamino-3-alkyle en position 5 dans un mélange contenant de l'acide azotique. L'invention concerne en outre l'utilisation des produits qui en résultent pour préparer des dérivés de benzimidazol pharmaceutiquement actifs.

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