C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/82 (2006.01) A01H 5/00 (2006.01)
Patent
CA 2637363
The invention provides methods for selecting nucleotide sequences that yield dsRNA- mediated gene suppression in a target organism and enable their uptake by the target organism. The invention further provides expression constructs that confer stabilized expression of such sequences in a transgenic host cell, and methods for their use. Also provided are organisms, cells and tissues prepared by a method of the invention.
La présente invention concerne des procédés permettant de sélectionner des séquences de nucléotides qui entraînent la suppression d'un gène par l'intermédiaire de l'ARN double brin dans un organisme cible et permettent leur absorption par l'organisme cible. L'invention se rapporte également à des constructions d'expression qui confèrent une expression stabilisée desdites séquences dans une cellule hôte transgénique, ainsi qu'à leurs procédés d'utilisation. En outre, l'invention porte sur des organismes, des cellules et des tissus préparés grâce au procédé de l'invention.
Goley Jean C.
Heck Gregory R.
Johnson Scott C.
Munyikwa Tichafa R.i.
Roberts James K.
Mcfadden Fincham
Monsanto Technology Llc
LandOfFree
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