Ep4 receptor agonist, compositions and methods thereof

Details Ep4 receptor agonist, compositions and methods thereof Ep4 receptor agonist, compositions and methods thereof

C - Chemistry, Metallurgy

07

D

C07D 413/06 (2006.01) A61K 31/5355 (2006.01) A61P 19/00 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2616604

This invention relates to potent selective agonists of the EP4 subtype of prostaglandin E2 receptors, their use or a formulation thereof in the treatment of glaucoma and other conditions, which are related to elevated intraocular pressure in the eye of a patient. This invention further relates to the use of the compounds of this invention for mediating the bone modeling and remodeling processes of the osteoblasts and osteoclasts.

Cette invention porte sur de puissants agonistes sélectifs du sous-type EP4 des récepteurs E2 de la prostaglandine, sur leur utilisation ou sur une formulation de ceux-ci destinée à être utilisée dans le traitement du glaucome et autres états liés à une pression intraoculaire élevée chez le patient. Cette invention porte également sur l'utilisation des composés de l'invention afin d'induire des processus de modelage et de remodelage osseux par les ostéoblastes et les ostéoclastes.

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