Therapeutic agent for patients having human fc.gamma.riiia

Details Therapeutic agent for patients having human fc.gamma.riiia Therapeutic agent for patients having human fc.gamma.riiia

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61P 9/00 (2006.01) A61P 29/00 (2006.01) A61P 31/04 (2006.01) A61P 31/12 (2006.01) A61P 31/14 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) A61P 37/04 (2006.01) A61P 37/08 (2006.01) A61P 43/00 (2006.01) C07K 16/00 (2006.01) C07K 16/18 (2006.01) C07K 16/44 (2006.01) C12N 5/10 (2006.01) C12N 15/09 (2006.01) C12P 21/08 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01)

Patent

CA 2481925

A drug containing, as the active ingredient, an antibody composition produced with the use of cells tolerant to a lectin recognizing a sugar chain structure in which an .alpha.-bond is formed between the 6-position of N- acetylglucosamine at the reducing end of an N-glycoside bond-type complex sugar chain and the 1-position of fucose. This drug is appropriate for patients suffering from Fc.gamma.RIIIa polymorphism who cannot be treated with a drug containing, as the active ingredient, an antibody composition produced from cells not tolerant to a lectin recognizing a sugar chain structure in which an .alpha.-bond is formed between the 6-position of N-acetylglucosamine at the reducing end of an N-glycoside bond-type complex sugar chain and the 1- position of fucose.

L'invention porte sur un médicament contenant, comme ingrédient actif, une composition d'anticorps produite au moyen de cellules tolérantes à une lectine reconnaissant une structure en chaîne du sucre dans laquelle une liaison .alpha. est formée entre la position 6 de N-acétylglucosamine à l'extrémité réductrice de la chaîne de sucre complexe de type liaison N-glycoside et la position 1 du fucose. Ce médicament est approprié aux patients souffrant de polymorphisme Fc.gamma.RIIIa qui ne peut être traité avec un médicament contenant, comme ingrédient actif, une composition d'anticorps produite à partir de cellules non tolérantes à une lectine reconnaissant une structure en chaîne du sucre dans laquelle une liaison .alpha. est formée entre la position 6 de N-acétylglucosamine à l'extrémité réductrice d'une chaîne du sucre complexe de type liaison N-glycoside et la position 1 du fucose.

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