Fluorinated methyl beta-alanine derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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260/468.1, 260/5

C07D 205/08 (2006.01) A61K 31/16 (2006.01) A61K 31/195 (2006.01) A61K 31/22 (2006.01) A61K 31/27 (2006.01) C07K 5/06 (2006.01)

Patent

CA 1161450

ABSTRACT OF THE DISCLOSURE Beta-monofluoromethyl beta-alanine, beta- difluoromethyl beta-alanine and pharmaceutically acceptable esters and amides derived from the acid group, amides and urethanes derived from the amine group, lactams and salts thereof are novel compounds which inhibit .gamma.-aminobutyric acid transaminase (GABA-T).

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