Therapeutic peptides and vaccines

A - Human Necessities – 61 – K

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A61K 39/21 (2006.01)

Patent

CA 2624957

Compositions are disclosed that induce broadly HIV theraputic and vaccine inducing antibodies against diverse HIV clades and relate to the ability to identify HIV gpl20-derived short peptide sequence immunogens and various therapeutic compositions made from the identified peptides which compose CCR5 binding sites. Also disclosed are methods of selecting peptide sequences that are likely candidates for drugs which will offer effective treatment in such areas as Alzheimer's disease, psoriasis, multiple sclerosis and other diseases associated with the human inflammatory cascade as well as related retroviruses such as HTLV-I, the cause of tropical spastic paraparesis.

La présente invention a trait à des compositions induisant de manière générale des agents thérapeutiques et des vaccins VIH induisant des anticorps contre diverses variantes A de VIH et concerne la capacité d'identifier des immunogènes à séquence peptidique courte dérivés de la gp120 du VIH et diverses compositions thérapeutiques produits à partir des peptides identifiés qui constituent des sites de liaison au CCR5. L'invention a également trait à des procédés de sélection de séquences peptidiques qui sont des candidats probables pour des médicaments qui vont permettre un traitement efficace dans de tels domaines tels que la maladie d'Alzheimer, le psoriasis, la sclérose en plaques et d'autres maladies associées à la cascade inflammatoire humaine ainsi qu'à des rétrovirus tels que le HTLV1, cause de la paraparèsie spastique tropicale.

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