Treatment of hemoglobin containing erythrocytes with nitric...

A - Human Necessities – 61 – K

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A61K 35/18 (2006.01) A61K 38/42 (2006.01) C07K 14/805 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2264792

Methods and compositions are provided for treating diluents (including whole blood or at least one blood component) comprising hemoglobin containing erythrocytes (i.e., red blood cells), in order to increase the oxygen delivery capacity of the hemoglobin, wherein nitric oxide is bound to most or all of the hemoglobin present in said erythrocytes as .alpha.-nitrosyl-hemoglobin or its oxygen bound forms.

La présente invention concerne des procédés et des compositions permettant de traiter des diluants chargés de sang total ou d'au moins un composant du sang, lesquels diluants contiennent de l'hémoglobine érythrocytaire. Ce traitement vise à augmenter la capacité de fourniture d'oxygène par l'hémoglobine. En l'occurrence, le monoxyde d'azote se lie à la totalité ou presque de l'hémoglobine présente dans les érythrocytes sous forme d'.alpha.-nitrosyl-hémoglobine ou de ses formes à liaison oxygène.

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