Improvement of tumour treatment

Details Improvement of tumour treatment Improvement of tumour treatment

C - Chemistry, Metallurgy

07

K

C07K 16/22 (2006.01) C07K 16/18 (2006.01) G01N 33/48 (2006.01) G01N 33/68 (2006.01) A61K 39/395 (2006.01) C07K 14/475 (2006.01) C07K 14/71 (2006.01)

Patent

CA 2754678

The patent discloses the use of Hepatocellular Carcinoma Related Protein 1(HCRP1) as a marker for the efficiency of an anti-EGFR antibody treatment of a tumour patient. If a tumour biopsy sample of the tumour patient reveals an HCRP1 protein or mRNA amount equal to or above the amount in normal, non-tumour tissue, then the tumour patient is eligible for the treatment with an anti-EGFR antibody.

La présente invention a pour objet l'utilisation de la protéine associée au carcinome hépatocellulaire 1 (HCRP1) en tant que marqueur de l'efficacité d'un traitement par anticorps anti-EGFR d'un patient atteint d'une tumeur. Si un échantillon de biopsie de tumeur du patient atteint d'une tumeur révèle une quantité de protéine HCRP1 ou d'ARNm égale ou supérieure à la quantité dans un tissu normal non tumoral, alors le patient atteint d'une tumeur est éligible au traitement par un anticorps anti-EGFR.

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