C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/06 (2006.01) A61K 31/4025 (2006.01) A61K 31/4439 (2006.01) A61P 3/10 (2006.01) A61P 25/28 (2006.01) C07D 207/36 (2006.01)
Patent
CA 2532068
The present invention relates to certain novel compounds of the Formula I to processes for preparing such compounds, to their the utility in modulation of nuclear hormone receptors Liver X Receptor (LXR) .alpha. (NR1H3) and/or .beta. (NR1H2) and in treating clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer~s disease, lipid disorders (dyslipidemias) whether or not associated with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, to methods for their therapeutic use and to pharmaceutical compositions containing them.
L'invention concerne de nouveaux composés représentés par la formule I, des procédés permettant de préparer de tels composés, et l'utilisation de ces composés pour la modulation des récepteurs hormonaux nucléaires RXH (récepteur X hépatique) a (NR1H3), ou .szlig. (NR1H2), et pour le traitement d'états cliniques comprenant les maladies cardiovasculaires telles que l'athérosclérose, les maladies inflammatoires, la maladie d'Alzheimer, les troubles lipidiques (dyslipidémies) associés ou non à une résistance insulinique, le diabète de type 2 ou d'autres manifestations d'un syndrome métabolique, ainsi que des méthodes d'utilisation thérapeutique de ces composés et des compositions pharmaceutiques les contenant.
Astrazeneca Ab
Fetherstonhaugh & Co.
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