C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 285/135 (2006.01) A61K 31/433 (2006.01) C07D 271/07 (2006.01) C07D 271/113 (2006.01) C07D 285/08 (2006.01) C07D 285/12 (2006.01)
Patent
CA 2561596
The present invention relates to compounds of the Formula (I) wherein R1, R3, R5, R7, X, Y and U are as defined. Compounds of the Formula (I) have activity inhibiting production of A.szlig.-peptide. The invention also relates to pharmaceutical compositions and methods of treating diseases and disorders, for example, neurodegenerative and/or neurological disorders, e.g., Alzheimer's disease, in a mammal comprising compounds of the Formula (I).
La présente invention a trait à des composés de formule (I) dans laquelle ; R?1¿, R?3¿, R?5¿, R?7¿, X, Y et U sont tels que définis dans la description. Les composés de formule (I) présentent une activité inhibitrice du peptide A.beta.. L'invention a également trait à des compositions pharmaceutiques et à des procédés de traitement de maladies et de troubles, par exemple, des troubles neurodégénératifs et/ou neurologiques, tels que la maladie d'Alzheimer, chez un mammifère comportant des composés de formule (I).
Pfizer Products Inc.
Torys Llp
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