Dermal delivery

Details Dermal delivery Dermal delivery

A - Human Necessities

61

K

A61K 9/51 (2006.01) A61K 31/48 (2006.01)

Patent

CA 2726836

The present invention describes systems and methods for treating disorders and/or conditions associated with the dermal level of the skin. Such disorders include acne, hyperhidrosis, bromhidrosis, chromhidrosis, rosacea, hair loss, dermal infec-tion, and/or actinic keratosis. Methods generally involve administering nanoemulsions (e.g., nanoparticle compositions) compris-ing at least one therapeutic agent, such as botulinum toxin. In some embodiments, nanoemulsions are prepared, e.g., by high pres-sure microfluidization, and comprise a particle size distribution exclusively between 10 nm and 300 nm.

La présente invention porte sur des systèmes et des procédés pour traiter des troubles et/ou états associés au niveau dermique de la peau. De tels troubles comprennent l'acné, l'hyperhidrose, la bromhidrose, la chromhidrose, la rosacée, la chute des cheveux, une infection dermique et/ou une kératose actinique. Les procédés mettent en jeu d'une manière générale l'administration de nanoémulsions (par exemple, des compositions de nanoparticules) comprenant au moins un agent thérapeutique, telle que la toxine botulinique. Dans certains modes de réalisation, des nanoémulsions sont préparées, par exemple, par microfluidisation haute pression, et comprennent une distribution de la dimension de particule exclusivement entre 10 nm et 300 nm.

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