Stabilized extended release pharmaceutical compositions...

Details Stabilized extended release pharmaceutical compositions... Stabilized extended release pharmaceutical compositions...

A - Human Necessities

61

K

A61K 31/138 (2006.01) A61K 9/28 (2006.01) A61K 47/30 (2006.01)

Patent

CA 2625676

The present invention is a new stable extended release drug composition particularly suitable for use as a beta-adrenoreceptor antagonist agent. The present invention is specifically a drug composition comprising a pharmaceutical, a methacrylic acid copolymer and a matrix forming agent, and a method for manufacturing same. When applied to highly soluble drugs like metoprolol succinate, the resulting drug composition is characterized by an extended-release profile.

La présente invention concerne une nouvelle composition médicamenteuse stable à libération retardée d~une utilisation particulièrement appropriée comme agent antagoniste de bêta-adrénorécepteur. Spécifiquement, la présente invention est une composition médicamenteuse qui comprend un médicament, un copolymère d~acide méthacrylique et un agent formateur de matrice, et une méthode pour la fabriquer. Lorsqu~elle est appliquée à des médicaments très solubles comme du succinate de métoprolol, la composition médicamenteuse résultante est caractérisée par un profil de libération retardée.

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