Use of tyloxapol as a nanoparticle stabilizer and dispersant

Details Use of tyloxapol as a nanoparticle stabilizer and dispersant Use of tyloxapol as a nanoparticle stabilizer and dispersant

A - Human Necessities

61

K

A61K 31/203 (2006.01) A61K 9/14 (2006.01) A61K 9/51 (2006.01) A61K 47/34 (2006.01) A61K 49/04 (2006.01)

Patent

CA 2108192

The present invention is directed to a composition comprised of nanoparticles having tyloxapol adsorbed on the surface thereof. In a preferred embodiment, said nanoparticle contains a diagnostic or therapeutic agent therein. In a further preferred embodiment, the nanoparticles contain a further surface modifier associated therewith. This invention further discloses a method of making nanoparticles having tyloxapol adsorbed on the surface, said method comprising contacting said nanoparticles with tyloxapol for a time and under conditions sufficient to provide a nanoparticle-tyloxapol composition. The present invention is also directed to a method of diagnosis comprising administering to a mammal a contrast effective amount of particles of nanoparticles having tyloxapol adsorbed on the surface thereof, and generating a diagnostic image of said mammal.

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