Adhesion receptor antagonists iii

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 263/20 (2006.01) A61K 31/42 (2006.01) A61K 31/505 (2006.01) C07D 263/24 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2132579

Abstract Novel oxazolidinone derivatives of the formula I Image I, in which R1 is a phenyl radical which is unsubstituted or is monosubstituted by CN, H2N-CH2-, A2N-CH2-, H2N-C(=NH)-, H2N-C(=NH)-NH-, H2N-C(=NH)-NH-CH2-, HO-NH-C(=NH)- or HO-NH-C(=NH)-NH-, X is O, S, SO, SO2, -NH- or -NA-, B is Image or Image A is alkyl having from 1 to 6 C atoms, R2 is H, A, Li, Na, K, NH4 or benzyl, R3 is H or (CH2)n-COOR2, E is, in each case independently of each other, CH or N, Q is O, S or NH m is 1, 2 or 3, and n is 0, 1, 2 or 3, and physiologically harmless salts thereof, inhibit the binding of fibrinogen to the corresponding receptor and can be used for treating thrombosis, stroke, cardiac infarction, inflammations, arteriosclerosis, osteoporosis and also tumours.

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