C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 13/04 (2006.01) C07C 233/83 (2006.01) C07D 263/42 (2006.01) C07D 263/44 (2006.01) C12P 41/00 (2006.01)
Patent
CA 2173205
A novel azlactone of formula (<u>3</u>), or the opposite enatiomer, wherein R1, R2, R3 and X are each a substituent, undergoes biotransformation, using suitable enzymatic activity, in the presence of a base YH to form an N-acyl- amino-acid of formula (<u>2</u>), wherein Y is a group derivable from the base YH and convertable to OH. An amino-acid of formula (<u>1</u>), or the opposite enantiomer, can be prepared in high e.e. from a compound of formula (<u>2</u>) by converting Y to OH.
Selon l'invention, on soumet à une biotransformation une nouvelle azlactone de la formule (<u>3</u>), ou l'énantiomère opposé, dans laquelle R?1¿, R?2¿, R?3¿ et X sont chacun un substituant, en utilisant une activité enzymatique appropriée, en présence d'une base YH pour former un amino-acide N-acyle de la formule (<u>2</u>) dans laquelle Y est un groupe que l'on peut dériver de la base YH et convertir en OH. On peut préparer un amino-acide de la formule (<u>1</u>), ou l'énantiomère opposé, en excès énantiomère élevé à partir d'un composé de la formule (<u>2</u>) en convertissant Y en OH.
Mccague Raymond
Turner Nicholas
Winterman James
Borden Ladner Gervais Llp
Chirotech Technology Limited
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