A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/496 (2006.01) A61K 31/198 (2006.01) A61K 31/216 (2006.01) A61K 31/381 (2006.01) A61K 31/395 (2006.01) A61K 31/397 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/4164 (2006.01) A61K 31/427 (2006.01) A61K 31/44 (2006.01) A61K 31/445 (2006.01) A61K 31/47 (2006.01) A61K 31/472 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) A61K 31/506 (2006.01) A61K 31/5375 (2006.01) A61K 31/54 (2006.01) A61K 31/541 (2006.01) A61K 31/56 (2006.01) A61K 38/21 (2006.01) A61P 29/00 (2006.01)
Patent
CA 2514117
The application provides for methods and compositions for inhibiting demyelination, promoting remyelination and/or treating paralysis in a subject in need thereof. Preferably, such compositions include immunoglobulins (e.g., antibodies, antibody fragments, and recombinantly produced antibodies or fragments), polypeptides (e.g., soluble forms of the ligand proteins for integrins) and small molecules, which when administered in an effective amount inhibits demyelination and/or promotes remyelination in a patient. The compositions and methods described herein can also utilize other anti- inflammatory agents used to palliate conditions and diseases associated with demyelination.
L'invention concerne des méthodes et des compositions destinées à inhiber la démyélinisation, à favoriser la remyélinisation et/ou à traiter la paralysie chez un sujet nécessitant un tel traitement. De préférence, ces compositions comprennent des immunoglobulines (par ex., des anticorps, des fragments d'anticorps et des anticorps produits par recombinaison ou des fragments correspondants), des polypeptides (par ex., des formes solubles des protéines ligands pour les intégrines) et des molécules de petite taille dont l'administration en dose efficace permet d'inhiber la démyélinisation et/ou de favoriser la remyélinisation chez un patient. Les compositions et les méthodes de l'invention peuvent également faire appel à d'autres agents anti-inflammatoires utilisés pour traiter les pathologies et les maladies associées à la démyélinisation.
Dressen Daren
Freedman Stephen
Grant Francine S.
Karlik Steve J.
Konradi Andrei W.
Barrigar Intellectual Property Law
Elan Pharmaceuticals Inc.
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