C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/40 (2006.01) A61K 39/395 (2006.01) C12P 21/08 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/573 (2006.01)
Patent
CA 2343720
An antibody recognizing a novel transmembrane matrix metalloprotease polypeptide [MT4-MMP(2)] which has a physiological activity different from MT4- MMP reported hitherto; preventives, diagnostics and remedies for various diseases such as arthrosis deformans, rheumatoid arthritis, asthma, autoimmune diseases and atopic dermatitis which contain the above antibody; a method for screening an MT4-MMP(2) inhibitor or activator by using the above antibody, etc. An antibody recognizing a novel human and mouse transmembrane matrix metalloprotease polypeptide MT5-MMP which has a physiological activity; preventives, diagnostics and remedies for various diseases such as arthrosis deformans, rheumatoid arthritis, asthma, autoimmune diseases, atopic dermatitis, brain failure such as cerebral stroke, and Alzheimer's disease which contain the above antibody; a method for screening an MT5-MMP inhibitor or activator by using the above antibody, etc.
La présente invention concerne un anticorps reconnaissant un nouveau polypeptide métalloprotéase de matrice transmembranaire [MT4-MMP(2)] qui a une activité physiologique différente de MT4-MMP rapportée jusqu'ici, des agents prophylactiques, des agents de diagnostic et des remèdes contre diverses maladies telles que l'arthrose, l'arthrite rhumatoïde, l'asthme, les maladies auto-immunes et la dermatite atopique, qui contiennent l'anticorps susmentionné, ainsi qu'un procédé d'utilisation dudit anticorps, etc. La présente invention concerne en outre un anticorps reconnaissant un nouveau polypeptide humain et de souris métalloprotéase de matrice transmembranaire MT5-MMP qui possède une activité physiologique, des agents prophylactiques, des agents de diagnostic et des remèdes contre diverses maladies telles que l'arthrose, l'arthrite rhumatoïde, l'asthme, les maladies auto-immunes, la dermatite atopique, les troubles cérébraux tels que l'accident vasculaire cérébral, et la maladie d'Alzheimer, qui contiennent l'anticorps susmentionné, ainsi que méthode de criblage d'un inhibiteur ou activateur de MT5-MMP à l'aide dudit anticorps, etc.
Furuya Akiko
Hanai Nobuo
Goudreau Gage Dubuc
Kyowa Hakko Kogyo Co. Ltd.
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