Topical delivery of peptides/proteins entrapped in...

A - Human Necessities – 61 – K

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A61K 9/127 (2006.01) A61K 38/21 (2006.01) A61M 37/00 (2006.01)

Patent

CA 2038945

2038945 9101719 PCTABS00003 This invention concerns a topical delivery of small peptides/proteins into the deep tissue of the skin via intradermal permeation. Small peptides/proteins entrapped in liposomes prepared by dehydration/rehydration method and delivered topically via an intradermal route are useful in treatment of various diseases by depositing the entrapped peptide into the epithelial cells of the deeper tissue of the skin. In particular, this invention is useful in suppression of the development of skin lesions induced by virus, bacteria, inflammation or other causes by treatment of the infected epithelial cells with liposome entrapped small peptide able to reduce the damage to the epithelial cells or inhibit viral replication and expression.

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