Melanocyte stimulating hormone receptor and uses

Details Melanocyte stimulating hormone receptor and uses Melanocyte stimulating hormone receptor and uses

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 38/34 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 14/72 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 5/18 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2133843

The present invention relates to a mammalian melanocyte stimulating hormone receptor. The invention is directed toward the isolation, characterization and pharmacological use of mammalian melanocyte stimulating hormone receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing a mammalian melanocyte stimulating hormone receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize mammalian melanocyte stimulating hormone receptor. The invention also provides methods for screening MSH R agonists and antagonists in vitro using preparations of receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the MSH R receptor gene. The invention specifically provides human and mouse MSH R genes.

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