Imidazopyridazines, their production and use

C - Chemistry – Metallurgy – 07 – D

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C07D 487/04 (2006.01) A61K 31/50 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2036977

An imidazo [1,2-b]pyridazine compound of the formula (I): Image wherein R1 is a halogen atom or a lower alkyl group optionally having substituent(s), R2 and R3 are, independently, a hydrogen atom, a lower alkyl group optionally having substituent(s), a cycloalkyl group or a phenyl group optionally having substituent(s) or R2 and R3 together with the adjacent nitrogen atom to which they bond may form a heterocyclic ring optionally having substituent(s), X is an oxygen atom or S(O)k (k is zero to two), a group Image is a bivalent three to seven membered homocyclic or heterocyclic group optionally having substituent(s), m1 and m2 each is an integer of 0 to 4 and n is an integer of 0 or 1; or its salt, which is useful as antiasthmatics..

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