Apoptosis-inducing antineoplastic silver (i) coordination...

A - Human Necessities – 61 – K

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A61K 31/555 (2006.01) A61K 31/194 (2006.01) A61P 1/16 (2006.01) A61P 35/00 (2006.01) C07F 1/10 (2006.01)

Patent

CA 2593321

The present invention describes chemotherapeutic compositions, a method for making the same, and methods for inducing apoptosis in tumor cells and/or inhibiting tumors. The compositions are metal coordination complexes of a cytotoxic metal, such as silver(I) and a chiral .alpha.-organic acid, such as tartaric acid, in a pharmaceutical carrier.

La présente invention concerne des compositions chimiothérapeutiques, une méthode de fabrication de celles-ci, et des méthodes d'induction de l'apoptose dans des cellules tumorales, et/ou d'inhibition des tumeurs. Lesdites compositions sont des complexes de coordination d'un métal cytotoxique, tel que l'argent (I), et d'un acide a-organique chiral, tel que l'acide tartrique, dans un excipient pharmaceutique.

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