C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 237/20 (2006.01) A61K 31/24 (2006.01) A61K 31/27 (2006.01) A61K 31/341 (2006.01) C07C 237/22 (2006.01) C07C 271/20 (2006.01) C07C 275/04 (2006.01) C07C 279/12 (2006.01) C07C 311/18 (2006.01) C07D 307/42 (2006.01)
Patent
CA 2599562
This invention provides certain compounds, methods of their preparation, pharmaceutical compositions comprising the compounds, their use in treating human or animal disorders. The compounds of the invention are useful as modulators of the interaction between the receptor for advanced glycated end products (RAGE) and its ligands, such as advanced glycated end products (AGEs), S100/calgranulin/EN-RAGE, .beta..beta.-amyloid and amphoterin, and for the management, treatment, control, or as an adjunct treatment for diseases in humans caused by RAGE. Such diseases or disease states include acute and chronic inflammation, the development of diabetic late complications such as increased vascular permeability, nephropathy, atherosclerosis, and retinopathy, the development of Alzheimer's disease, erectile dysfunction, and tumor invasion and metastasis.
Avor Kwasi
Gopalaswamy Ramesh
Mjalli Adnan
Patron Andrew
Wysong Christopher
Moffat & Co.
Transtech Pharma Inc.
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