Production of f(ab')2 fragments in mammalian cells

Details Production of f(ab')2 fragments in mammalian cells Production of f(ab')2 fragments in mammalian cells

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C12N 5/10 (2006.01) C12N 15/13 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2470579

The present invention provides immortalized eucaryotic cells and methods useful for the production of immunologically active bivalent antibody fragments, such as F(ab')2 fragments. The methods and cells of the invention result in a desirable ratio of bivalent to monovalent antibody fragments.

L'invention concerne des cellules eurocaryotes immortalisées et des procédés utiles pour la production de fragments d'anticorps bivalents immunologiquement actifs, tels que des fragments F(ab')2. Lesdits procédés et cellules de l'invention provoquent un rapport souhaité de fragments d'anticorps bivalents à des fragments d'anticorps monovalents.

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