Liver x receptor .alpha. splicing mutant protein, gene...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 14/705 (2006.01) A01K 67/027 (2006.01) C07K 16/28 (2006.01) C12N 1/15 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 5/00 (2006.01) C12N 15/12 (2006.01) C12P 21/02 (2006.01) C12Q 1/02 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2525870

It is intended to provide a liver X receptor .alpha. splicing mutant protein which is an isoform of liver X receptor .alpha. and at least has an amino acid sequence encoded by the exon 5 of liver X receptor .alpha. gene, its gene and utilization of the same, which are usable in developing methods useful in preventing, diagnosing and treating diseases and injuries relating to the inhibition of the normal cholesterol metabolism by the normal type liver X receptor .alpha., drugs therefor and so on.

L'invention concerne une protéine mutante d'épissage du récepteur X .alpha. du foie qui est une isoforme du récepteur X .alpha. du foie et qui comprend au moins une séquence d'acide aminé codée par l'exon 5 du gène du récepteur X .alpha. du foie, son gène ainsi que leur utilisation. Cette protéine et ce gène peuvent être utilisés pour développer des méthodes destinées à prévenir, diagnostiquer et traiter des maladies et des lésions associées à l'inhibition du métabolisme du cholestérol normal par le récepteur X .alpha. du foie de type normal, des médicaments associés, etc.

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