G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) C07K 14/47 (2006.01) C07K 14/62 (2006.01) C07K 14/705 (2006.01) G01N 33/74 (2006.01)
Patent
CA 2380983
According to the invention .beta.-tubulin, as well as a 65 kDa polypeptide present in pancreatic .beta.-cells, have been identified as molecular targets for sulfonylurea compounds. These findings enable for the identification of new insulin secretagogues. The invention thus relates to the use of sulfonylurea compounds, such as e.g. glibenclamide, in methods for identification of compounds binding the 65 kDa polypeptide or tubulin, or stimulating tubulin polymerization and/or turnover, said compounds thereby stimulating insulin secretion.
L'invention concerne une .beta.-tubuline et un polypeptide 65 kDa, présents dans les cellules .beta. pancréatiques, qui ont été identifiés comme cibles moléculaires pour les composés de sulfonylurée. Ces découvertes permettent l'identification de nouveaux sécrétagogues d'insuline. L'invention concerne aussi l'utilisation des composés de sulfonylurée tels que le glibenclamide, dans des procédés d'identification de composés se liant avec le polypeptide 65 kDa ou la tubuline ou stimulant la polymérisation de la tubuline et/ou son renouvellement, ces composés stimulant de ce fait la sécrétion d'insuline.
Berggren Per-Olof
Bertorello Alejandro
Lundback Thomas
Biovitrum Ab
Gowling Lafleur Henderson Llp
Karolinska Innovations Ab
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