Thienopyrrolidinones

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 495/04 (2006.01) A61K 31/407 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2414705

The present invention provides substituted thieno[2,3-b]pyrrolidin-5-ones of formula (I) wherein R1, R2, and R3 have the values given in the specification. The compounds are useful as inhibitors of cellular production of tumour necrosis factor (TNF-.alpha.) and as antiproliferative agents and, therefore, may find use in the treatment of neuro-degenerative diseases, cardiovascular diseases, cancer or inflammatory diseases.

La présente invention concerne des thiéno[2,3-b]pyrrolidin-5-ones substituées de formule (I). Dans cette formule, R?1¿, R?2¿ et R?3¿ ont les valeurs données dans le descriptif. Ces composés sont utiles en tant qu'inhibiteurs de la production cellulaire du facteur de nécrose des tumeurs (TNF-.alpha.) et en tant qu'agents antiprolifératifs et on peut par conséquent les utiliser dans le traitement des maladies neurodégénératives, des maladies cardio-vasculaires, du cancer ou des maladies inflammatoires.

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