C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07K 14/435 (2006.01) C12Q 1/26 (2006.01) G01N 33/92 (2006.01)
Patent
CA 2516023
The invention relates to the use of C. elegans as a model for identifying genes that are involved in lipid or lipoprotein metabolism and which can serve as drug targets. The invention also provides a system for screening drugs useful in the treatment and prevention of diseases associated with undesirable or abnormal levels of lipids (e.g., cholesterol) or lipoproteins (e.g., LDL), such as cardiovascular disorders and dyslipidemia.
La présente invention concerne l'utilisation de C.elegansen tant que modèle pour identifier des gènes qui sont impliqués dans le métabolisme des lipides ou des lipoprotéines et qu'on peut utiliser en tant que cibles pour des médicaments. La présente invention se rapporte également à un système de criblage de médicaments utiles dans le traitement et la prévention des maladies associées à des taux défavorables ou anormaux de lipides (par exemple, le cholestérol) ou de lipoprotéines (par exemple LDL) telles que les troubles cardio-vasculaires et la dyslipidémie.
Branicky Robyn
Hekimi Siegfried
Shibata Yukimasa
Robic
University Mcgill
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