A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/40 (2006.01) A61K 31/437 (2006.01) A61K 31/4468 (2006.01) A61P 3/06 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2626422
The invention is directed to methods for treating hyperlipidemia in a mammal. The methods involve combination therapies using a microsomal triglyceride transfer protein (MTP) inhibitor (for example, BMS-201038 and implitade) and a cholesterol absorption inhibitor (CAI) (for example, ezetimibe). Co- administration of the MTP inhibitor with the CAI produces a therapeutic benefit, for example, a reduction in the concentration of cholesterol and/or triglycerides in the blood stream, but with fewer or reduced side effects than when higher dosages of the MTP inhibitor are used during monotherapy to provide the same or similar therapeutic benefit.
L'invention concerne des méthodes permettant de traiter l'hyperlipidémie chez un mammifère. Ces méthodes font intervenir des traitements combinés utilisant un inhibiteur de protéine microsomale de transfert des triglycérides (MTP) (par exemple, BMS-201038 et implitade) et un inhibiteur d'absorption du cholestérol (CAI) (par exemple, ezetimibe). La co-administration de l'inhibiteur MTP et du CAI produit un effet thérapeutique bénéfique, par exemple, une réduction de la concentration de cholestérol et/ou de triglycérides dans la circulation sanguine mais avec effets secondaires moindres que lorsque des dosages élevés de l'inhibiteur MTP sont utilisés dans une monothérapie afin d'obtenir un effet thérapeutique bénéfique identique ou semblable.
Aegerion Pharmaceuticals
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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